antimicrobial peptides (amps)
نویسندگان
چکیده
antimicrobial peptides (amps) are extensive group of molecules that produced by variety tissues of invertebrate, plants, and animal species which play an important role in their immunity response. amps have different classifications such as; biosynthetic machines, biological sources, biological functions, molecular properties, covalent bonding patterns, three dimensional structures, and molecular targets. these molecules have multidimensional properties including antimicrobial activity, antiviral activity, antifungal activity, anti-parasite activity, biofilm control, antitumor activity, mitogens activity and linking innate to adaptive immunity that making them promising agents for therapeutic drugs. in spite of this advantage of amps, their clinical developments have some limitation for commercial development. but some of amps are under clinical trials for the therapeutic purpose such as diabetic foot ulcers, different bacterial infections and tissue damage. in this review, we emphasized on the source, structure, multidimensional properties, limitation and therapeutic applications of various antimicrobial peptides.
منابع مشابه
Antimicrobial Peptides (AMPs)
Antimicrobial peptides (AMPs) are extensive group of molecules that produced by variety tissues of invertebrate, plants, and animal species which play an important role in their immunity response. AMPs have different classifications such as; biosynthetic machines, biological sources, biological functions, molecular properties, covalent bonding patterns, three dimensional structures, and molecul...
متن کاملCovalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces.
Bacterial adhesion to biomaterials remains a major problem in the medical devices field. Antimicrobial peptides (AMPs) are well-known components of the innate immune system that can be applied to overcome biofilm-associated infections. Their relevance has been increasing as a practical alternative to conventional antibiotics, which are declining in effectiveness. The recent interest focused on ...
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The worldwide emergence of bacterial superbugs, and the limited number of effective antibiotic against them, has become an unresolved public catastrophe. According to a report from the World Health Organization in 2014, the resistance rate in a common bacterial pathogen such as Escherichia coli is high enough to limit the efficacy of currently available oral treatment options for patients with ...
متن کاملInteraction between antimicrobial peptides (AMPs) and their primary target, the biomembranes
Antimicrobial peptides (AMPs) are produced by almost all living organisms as a component of their immune system representing the first line weapons against infective agents. During the past two decades these key factors of the innate immunity have been isolated from many different organisms including mammals, insects, plants; bacteria and amphibians. Although AMPs are an heterogeneous group of ...
متن کاملAntimicrobial Peptides Derived from Milk: A Review
Milk proteins provide a natural source of bioactive peptides with potential health benefits and applications in the food industry. The release of these peptides from milk proteins is achieved either by hydrolysis using digestive proteases or by lactic acid bacteria fermentation. Peptides, particularly those derived from milk proteins, can exert a wide range of nutritional, functional and biolog...
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عنوان ژورنال:
novelty in biomedicineجلد ۴، شماره ۲، صفحات ۷۰-۷۶
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